Frizzled-5 Recombinant Protein

Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.

Specyfikacja/Zawartość:

• Tested Applications: N/A
• Applications: This recombinant proteins is for research use only.
• Predicted Molecular Weight: N/A
• Physical state: Lyophilized
• Buffer: Contains PBS. Reconstitute with 50 µl sterile water.
• Concentration: 1mg/ml after reconstitution.
• NCBI official symbol: FZD5
• Accession #: Q13467
• Protein GI: 27894385
• NCBI gene ID#: 7855
• NCBI official full name: frizzled class receptor 5
• NCBI organism: Homo sapiens
• Peptide sequence: N/A
• SWISSPROT #: Q9Y6F1
• Background Reference 1: N/A
• Background Reference 2: N/A
• Background Reference 3: N/A
• Background Reference 4: N/A
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Human, Mouse
• By Source: Human Cells
• By Species: Human, Mouse
• Fusion tag: Fc Tag
• Sequence: The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
• Biology activity: Inhibits Wnt3a activation in a stoechiometric manner.
• Purity: >95% (SDS-PAGE).
• Endotoxin level is less than 0.01EU/ µg purified protein (LAL test
• Lonza).

Wysyłka i przechowywanie:

Stable for at least 6 months after receipt when stored at -20°C.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.