JBJ-03-142-02

JBJ-03-142-02

Dodatkowe informacje:

• SMILES: Cn1cc(Nc2nccc(n2)N(C(=O)OCc2ccc(F)cc2)c2cccc(NC(=O)C=C)c2)cn1
• Formula: C25H22FN7O3

Specyfikacja/Zawartość:

• Purity: 0.98
• CAS#: 2068806-31-3
• Molecular Weight: 487.495
• Bioactivity: Highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor
• HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion
• Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.

Inne:

For research use only.