CL2 Linker

CL2 Linker

Dodatkowe informacje:

• SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@H](C(NC2=CC=C(COC(N(CCN(C(OCC(CO)=O)=O)C)C)=O)C=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(CCCCCN4C(=O)C=CC4=O)=O)N=N3)=O
• Formula: C68H103N11O22

Specyfikacja/Zawartość:

• Purity: 0.98
• CAS#: 2270986-66-6
• Molecular Weight: 1426.61
• Bioactivity: CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

Inne:

For research use only.