Rec 15/2615 (hydrochloride)

Rec 15/2615 (hydrochloride)

Dodatkowe informacje:

• SMILES: O=C(COC1=C(C(C)C)C=CC=C1OC)N2CCN(CC2)C3=NC4=C(C=C(C(OC)=C4)OC)C(N)=N3.Cl.Cl
• Formula: C26H35Cl2N5O5

Specyfikacja/Zawartość:

• Purity: 0.98
• CAS#: 1782573-48-1
• Molecular Weight: 568.49
• Bioactivity: Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs
• Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM).2 It decreases diastolic blood pressure (ED25 = 183 μg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 μg/kg.1,2

Inne:

For research use only.