TIGIT Detection Set

TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Dodatkowe informacje:

Optimal dilutions for each application to be determined by the researcher.

Specyfikacja/Zawartość:

• Host Species: llama
• Species Reactivity: Human
• Homology: N/A
• Immunogen: TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
• Tested Applications: E, IHC-P, ICC, IF, Flow
• Applications: N/A
• Specificity: N/A
• Purification: TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.
• Clonality: Monoclonal
• Isotype: sdab
• Conjugate: Unconjugated
• Physical State: Liquid
• Buffer: TIGIT Antibodies are supplied in PBS.
• Concentration: Antibody 1 mg/mL
• Set Contents: 20 µg:
• TIGIT Antibody [2B5], Cat. No. SD8824
• TIGIT Antibody [2F7], Cat. No. SD8827
• TIGIT Antibody [2C6], Cat. No. SD8828
• TIGIT Antibody [2C7], Cat. No. SD8829
• TIGIT Antibody [2D7], Cat. No. SD8830. 100 µg:
• cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
• Products: SD8824, SD8827, SD8828, SD8829, SD8830, PM-7669

Wysyłka i przechowywanie:

• TIGIT antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Shipping Condition: Dry Ice

Inne:

For Research Use Only