IRAK Detection Set

Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.;;For images please see PDF data sheet

Dodatkowe informacje:

Optimal dilutions for each application to be determined by the researcher.

Specyfikacja/Zawartość:

• Host Species: N/A
• Species Reactivity: Human
• Homology: N/A
• Immunogen: Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
• Tested Applications: WB, IHC, IF
• Applications: N/A
• Specificity: N/A
• Purification: Antibodies are supplied as affinity chromatography purified IgG.
• Clonality: Polyclonal
• Isotype: N/A
• Conjugate: N/A
• Physical State: Liquid
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: Antibody 1 mg/mL
• Peptide 200 µg/mL
• Set Contents: IRAK Antibody, Cat. No. 1007 (50 µg). IRAK-2 (C2) Antibody, Cat. No. 2123 (50 µg). IRAK-M Antibody, Cat. No. 2355 (50 µg). IRAK-4 Antibody, Cat. No. 3125 (50 µg). MyD88 Antibody, Cat. No. 2127 (50 µg)
• Products: 1007, 2123, 2355 , 3125, 2127

Wysyłka i przechowywanie:

• Stable at 4°C for three months, store at -20°C for up to one year.
• Shipping Condition: Not Specified

Inne:

For Research Use Only