COMMD7 Antibody

COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Cancer, Cell Cycle
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: Predicted species reactivity based on immunogen sequence: Bovine: (95%)
• Immunogen: COMMD7 antibody was raised against a 19 amino acid peptide near the center of human COMMD7.
• The immunogen is located within amino acids 90 - 140 of COMMD7.
• Tested Applications: E, WB, IHC-P, IF
• Applications: COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 μ
• g/ml. Antibody can also be used for Immunohistochemistry starting at 5 μ
• g/mL. For immunofluorescence start at 20 μ
• g/mL.
• Antibody validated: Western Blot in mouse samples
• Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.
• Positive control 1: Cat. No. 1406 - Mouse Spleen Tissue Lysate
• Positive control 2: Cat. No. 10-901 - Human Spleen Tissue Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 22 kDa
• Observed: 21 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: COMMD7 antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: COMMD7 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: COMMD7
• Accession #: NP_444269
• Protein GI #: 151101369
• NCBI gene ID#: 149951
• NCBI official full name: COMM domain containing 7
• NCBI organism: homo sapiens
• SWISSPROT #: Q86VX2

Wysyłka i przechowywanie:

• COMMD7 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year.

Inne:

Optimal dilutions for each application to be determined by the researcher.