LPIN1 Antibody

LPIN1 Antibody: LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol (reviewed in 1). LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1,2). Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3,4) and it is also a candidate for several human lipodystrophy syndromes (5).

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Stem Cell
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: LPIN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LPIN1.
• The immunogen is located within the last 50 amino acids of LPIN1.
• Tested Applications: E, WB, IHC-P, IF
• Applications: LPIN1 antibody can be used for detection of LPIN1 by Western blot at 1 - 2 μ
• g/mL.
• Antibody validated: Western Blot in human samples
• Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: LPIN1 antibody is human and mouse reactive. At least four isoforms of LPIN1 are known to exist.
• Positive control 1: Cat. No. 1204 - K562 Cell Lysate
• Positive control 2: Cat. No. 11-801 - Human Small Intestine Tissue Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 107 kDa
• Observed: 125 kDa
• MW explanation: Other LPIN1 antibodies show similar size band
• Validation: N/A
• Isoforms: N/A
• Purification: LPIN1 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: LPIN Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: LPIN1
• Accession #: NP_001248357
• Protein GI #: 387528013
• NCBI gene ID#: 23175
• NCBI official full name: lipin 1
• NCBI organism: homo sapiens
• SWISSPROT #: Q14693

Wysyłka i przechowywanie:

• LPIN antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year.

Inne:

Optimal dilutions for each application to be determined by the researcher.