TLX3 Antibody

TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Stem Cell
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3.
• The immunogen is located within the first 50 amino acids of TLX3.
• Tested Applications: E, WB, IHC-P, IF
• Applications: TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μ
• g/mL.
• Antibody validated: Western Blot in human samples
• Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: TLX3 antibody is predicted to not cross-react with other TLX proteins.
• Positive control 1: Cat. No. 1306 - Human Spleen Tissue Lysate
• Positive control 2: Cat. No. 10-901 - Human Spleen Tissue Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 32 kDa
• Observed: 30 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: TLX3 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: TLX3
• Accession #: NP_066305
• Protein GI #: 50355978
• NCBI gene ID#: 30012
• NCBI official full name: T-cell leukemia homeobox 3
• NCBI organism: homo sapiens
• SWISSPROT #: O43711

Wysyłka i przechowywanie:

• TLX3 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year.

Inne:

Optimal dilutions for each application to be determined by the researcher.