KANK2 Antibody

KANK2 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK2 (KN motif and ankyrin repeat domain-containing protein 2), was initially identified as a steroid receptor coactivator (SRC) interacting protein (SIP) that could sequester steroid receptor coactivators in the cytoplasm. More recent experiments have shown that while KANK2 is widely expressed, in kidney podocytes, KANK2 localizes to foot processes, suggesting that KANK2 may contribute to controlling actin dynamics in podocyte foot processes.

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Cancer, Cell Cycle
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: Predicted species reactivity based on immunogen sequence: Bovine: (94%)
• Immunogen: KANK2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human KANK2 .
• The immunogen is located within the last 50 amino acids of KANK2.
• Tested Applications: E, WB, IHC-P, IF
• Applications: KANK2 Antibody can be used for detection of KANK2 by Western blot at 1 μ
• g/mL.
• Antibody validated: Western Blot in mouse samples
• Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: Two alternatively spliced transcript variants encoding different isoforms have been identified.
• Positive control 1: Cat. No. 1403 - Mouse Brain Tissue Lysate
• Positive control 2: Cat. No. 10-401 - Human Kidney Tissue Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 95 kDa
• Observed: 102 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: KANK2 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: KANK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: KANK2
• Accession #: NP_056308
• Protein GI #: 258613875
• NCBI gene ID#: 25959
• NCBI official full name: KN motif and ankyrin repeat domains 2
• NCBI organism: homo sapiens
• SWISSPROT #: Q63ZY3

Wysyłka i przechowywanie:

• KANK2 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year.

Inne:

Optimal dilutions for each application to be determined by the researcher.