BCL3 Antibody

BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ-B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ-B proteins. The expression of this gene can be induced by NF-κ-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ-B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Cancer, Cell Cycle
• Host species: Rabbit
• Species reactivity: Human
• Homology: N/A
• Immunogen: Rabbit polyclonal BCL3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human BCL3.
• The immunogen is located within amino acids 360 - 410 of BCL3.
• Tested Applications: E, WB
• Applications: BCL3 antibody can be used for detection of BCL3 by Western blot at 1 - 2 μ
• g/mL.
• Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: Cat. No. 1210 - HEK293 Cell Lysate
• Positive control 2: N/A
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: Predicted: 50 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: BCL3 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: BCL3
• Accession #: NP_005169
• Protein GI #: 164664508
• NCBI gene ID#: 602
• NCBI official full name: B-cell CLL/lymphoma 3
• NCBI organism: homo sapiens
• SWISSPROT #: P20749

Wysyłka i przechowywanie:

• BCL3 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year.

Inne:

Optimal dilutions for each application to be determined by the researcher.