CMPK2 Antibody

CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Immunology
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2.
• The immunogen is located within amino acids 370 - 420 of CMPK2.
• Tested Applications: E, WB, IF
• Applications: CMPK2 antibody can be used for detection of CMPK2 by Western blot at 1 μ
• g/mL. For immunofluorescence start at 20 μ
• g/mL.
• Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: Multiple isoforms of CMPK2 are known to exist.
• Positive control 1: Cat. No. 1462 - Rat Lung Tissue Lysate
• Positive control 2: Cat. No. 10-101 - Human Lung Tissue Slide
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: 49 kDa
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: CMPK2 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: CMPK2
• Accession #: NP_997198
• Protein GI #: 117606370
• NCBI gene ID#: 129607
• NCBI official full name: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
• NCBI organism: homo sapiens
• SWISSPROT #: Q5EBM0

Wysyłka i przechowywanie:

• CMPK2 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Inne:

Optimal dilutions for each application to be determined by the researcher.