CD33 Antibody

CD33 Antibody: CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimer's disease.

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Stem Cell
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: CD33 antibody was raised against a 14 amino acid synthetic peptide near the center of human CD33.
• The immunogen is located within amino acids 180 - 230 of CD33.
• Tested Applications: E, WB
• Applications: CD33 antibody can be used for detection of CD33 by Western blot at 1 - 2 μ
• g/mL.
• Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
• Specificity: At least three isoforms of CD33 are known to exist
• this antibody will detect all three isoforms.
• Positive control 1: Cat. No. 1282 - 3T3 (NIH) Cell Lysate
• Positive control 2: N/A
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: CD33 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: CD33 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: CD33
• Accession #: NP_001763
• Protein GI #: 130979981
• NCBI gene ID#: 945
• NCBI official full name: CD33 molecule
• NCBI organism: Homo sapiens
• SWISSPROT #: P20138

Wysyłka i przechowywanie:

• CD33 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Inne:

Optimal dilutions for each application to be determined by the researcher.