LGI2 Antibody

LGI2 Antibody: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Neuroscience
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: LGI2 antibody was raised against a 11 amino acid synthetic peptide from near the amino terminus of human LGI2.
• The immunogen is located within the first 50 amino acids of LGI2.
• Tested Applications: E, WB
• Applications: LGI2 antibody can be used for the detection of LGI2 by Western blot at 1 - 2 μ
• g/mL.
• Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
• Specificity: This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins. Three isoforms of LGI2 are known to exist
• this LGI2 antibody will recognize only the longest.
• Positive control 1: Cat. No. 1210 - HEK293 Cell Lysate
• Positive control 2: N/A
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: LGI2 Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: LGI2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: Lgi2
• Accession #: Q8N0V4
• Protein GI #: 32469737
• NCBI gene ID#: 246316
• NCBI official full name: leucine-rich repeat LGI family, member 2
• NCBI organism: Mus musculus
• SWISSPROT #: Q8K4Z0

Wysyłka i przechowywanie:

• LGI2 antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Inne:

Optimal dilutions for each application to be determined by the researcher.