Aven Antibody

Aven Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Apoptosis, Cancer
• Host species: Rabbit
• Species reactivity: Human, Mouse, Rat
• Homology: N/A
• Immunogen: Aven antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Aven.
• The immunogen is located within the last 50 amino acids of Aven.
• Tested Applications: E, WB, IHC-P, IF
• Applications: Aven antibody can be used for detection of Aven by Western blot at 1 μ
• g/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ
• g/mL. For immunofluorescence start at 20 μ
• g/mL.
• Antibody validated: Western Blot in human samples
• Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
• Specificity: N/A
• Positive control 1: Cat. No. 1207 - Raji Cell Lysate
• Positive control 2: Cat. No. 1306 - Human Spleen Tissue Lysate
• Positive control 3: Cat. No. 10-901 - Human Spleen Tissue Slide
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: Aven Antibody is affinity chromatography purified via peptide column.
• Clonality: Polyclonal
• Clone: N/A
• Isotype: IgG
• Conjugate: Unconjugated
• Physical state: Liquid
• Buffer: Aven Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• NCBI official symbol: AVEN
• Accession #: NP_065104
• Protein GI #: 9966841
• NCBI gene ID#: 57099
• NCBI official full name: apoptosis, caspase activation inhibitor
• NCBI organism: Homo sapiens
• SWISSPROT #: Q9NQS1

Wysyłka i przechowywanie:

• Aven antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Inne:

Optimal dilutions for each application to be determined by the researcher.