TSLP Recombinant Protein

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

Specyfikacja/Zawartość:

• Tested Applications: WB
• Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 23-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Predicted Molecular Weight: 15.9 kDa
• Physical state: Lyophilized
• Buffer: PBS, pH7.4
• Concentration: N/A
• NCBI official symbol: Tslp
• Accession #: NP_067342.1
• Protein GI: N/A
• NCBI gene ID#: 53603
• NCBI official full name: thymicstromallymphopoietin
• NCBI organism: Mus musculus
• Peptide sequence: N/A
• SWISSPROT #: Q9JIE6
• Background Reference 1: Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015.
• Background Reference 2: Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
• Background Reference 3: Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.
• Background Reference 4: N/A
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Mouse
• By Source: Human Cells
• By Species: Mouse
• Fusion tag: His Tag
• Sequence: Tyr 20 - Glu 140
• Biology activity: N/A
• Purity: >90% as determined by SDS-PAGE.

Wysyłka i przechowywanie:

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.