FNDC5:Fc Recombinant Protein

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).

Specyfikacja/Zawartość:

• Tested Applications: N/A
• Applications: This recombinant proteins is for research use only.
• Predicted Molecular Weight: N/A
• Physical state: Lyophilized
• Buffer: Contains PBS. Reconstitute with 100 µl sterile water.
• Concentration: 0.1mg/ml after reconstitution.
• NCBI official symbol: FNDC5
• Accession #: Q8NAU1
• Protein GI: 403314395
• NCBI gene ID#: 252995
• NCBI official full name: fibronectin type III domain containing 5
• NCBI organism: Homo sapiens
• Peptide sequence: N/A
• SWISSPROT #: P13500
• Background Reference 1: N/A
• Background Reference 2: N/A
• Background Reference 3: N/A
• Background Reference 4: N/A
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Human, Mouse, Rat
• By Source: Human Cells
• By Species: Human, Mouse, Rat
• Fusion tag: Fc Tag
• Sequence: FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human.
• Biology activity: N/A
• Purity: >95% (SDS-PAGE).
• Endotoxin level is less than 0.01EU/ µg purified protein (LAL test
• Lonza).

Wysyłka i przechowywanie:

Stable for at least 6 months after receipt when stored at -20°C.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.