CD126 Recombinant Protein

Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

Specyfikacja/Zawartość:

• Tested Applications: WB
• Applications: This recombinant protein can be used for WB. For research use only.
• Predicted Molecular Weight: 40 kDa
• Physical state: Lyophilized
• Buffer: PBS, pH7.4
• Concentration: N/A
• NCBI official symbol: IL6R
• Accession #: NP_000556.1
• Protein GI: N/A
• NCBI gene ID#: 3570
• NCBI official full name: interleukin 6 receptor
• NCBI organism: Homo sapiens
• Peptide sequence: N/A
• SWISSPROT #: P08887
• Background Reference 1: Taga, T., et al., 1989, Cell (UNITED STATES) 58 (3): 573–81.
• Background Reference 2: Schooltink, H., 1992, FEBS Lett. (NETHERLANDS) 314 (3): 280–4.
• Background Reference 3: Yoshio-Hoshino, N. et al., 2007, Cancer. Res. 67: 871-875.
• Background Reference 4: Egler, R.A. et al., 2008, Clin. Cancer. Res. 14: 7028-7034.
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Human
• By Source: Human Cells
• By Species: Human
• Fusion tag: His Tag
• Sequence: Leu 20 - Pro 365
• Biology activity: Immobilized Human IL-6, Tag Free at 5ug/mL (100uL/well) can bind Human IL-6 R alpha, His Tag with a linear range of 1-16 ng/mL.
• Purity: >92% as determined by SDS-PAGE.

Wysyłka i przechowywanie:

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.