CD115 Recombinant Protein

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Specyfikacja/Zawartość:

• Tested Applications: WB
• Applications: This recombinant protein can be used for WB. For research use only.
• Predicted Molecular Weight: 55.1 kDa
• Physical state: Lyophilized
• Buffer: PBS, pH7.4
• Concentration: N/A
• NCBI official symbol: CSF1R
• Accession #: NP_005202.2
• Protein GI: N/A
• NCBI gene ID#: 1436
• NCBI official full name: colony stimulating factor 1 receptor
• NCBI organism: Homo sapiens
• Peptide sequence: N/A
• SWISSPROT #: P07333
• Background Reference 1: Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4): 1377–80.
• Background Reference 2: Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442–51.
• Background Reference 3: Tamimi, R. M., 2008, Cancer Research 68 (1): 18–21.
• Background Reference 4: Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312–6.
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Human
• By Source: Human Cells
• By Species: Human
• Fusion tag: His Tag
• Sequence: Ile 20 - Glu 512
• Biology activity: N/A
• Purity: >96% as determined by SDS-PAGE.

Wysyłka i przechowywanie:

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.