CD155 Recombinant Protein

CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that is encoded by the PVR gene. CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.

Specyfikacja/Zawartość:

• Tested Applications: E, WB
• Applications: This recombinant protein can be used for E, WB. For research use only.
• Predicted Molecular Weight: 62.2 kDa
• Physical state: Lyophilized
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Concentration: N/A
• NCBI official symbol: CD155
• Accession #: NP_006496.2
• Protein GI: N/A
• NCBI gene ID#: 5817
• NCBI official full name: poliovirus receptor isoform alpha precursor
• NCBI organism: Homo sapiens
• Peptide sequence: Trp 21 - Asn 343
• SWISSPROT #: P15151(340I/M)
• Background Reference 1: Zhang P., et al., 2008, Proc. Natl. Acad. Sci., 105 (47): 18284-18289.
• Background Reference 2: Maier MK., et al., 2007, European Journal of Immunology, 37 (8): 2214-2225.
• Background Reference 3: He Y., et al., 2000, Proc. Natl. Acad. Sci., 97 (1): 79-84.
• Background Reference 4: N/A
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Human
• By Source: Human Cells
• By Species: Human
• Fusion tag: mouse IgG2a Fc tag
• Sequence: Trp 21 - Asn 343
• Biology activity: Measured by its binding ability in a functional ELISA. Immobilized Human TIGIT, Fc Tag at 2 ug/mL (100 uL/well) can bind Human CD155, mouse IgG2a Fc tag with a linear range of 0.98-7.81 ng/mL.
• Purity: >95% as determined by SDS-PAGE.
• Endotoxin level is less than 0.1 EU per ug by the LAL method.

Wysyłka i przechowywanie:

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.