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Sophoridine
Numer katalogowy: 931-T3339-10mg
Kategoria produktu: Biznes i przemysł > Badania naukowe i laboratoryjne
Sprzedawca:Gentaur
Rozmiar:
10mg
Dostępność:
Na zamówienie
Cena:
0.01 PLN*
* Zapytaj o ofertę, aby otrzymać aktualną ofertę w 24h.
Sophoridine
Dodatkowe informacje:
- SMILES: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H](CN12)[C@@H]34
- Formula: C15H24N2O
Specyfikacja/Zawartość:
- Purity: 0.9928
- CAS#: 6882-68-4
- Molecular Weight: 248.37
- Bioactivity: Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.
Inne:
For research use only.
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