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5-Hydroxy-1-methylhydantoin
Numer katalogowy: 931-T28222-1g
Kategoria produktu: Biznes i przemysł > Badania naukowe i laboratoryjne
Sprzedawca:Gentaur
Rozmiar:
1g
Dostępność:
Na zamówienie
Cena:
0.01 PLN*
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5-Hydroxy-1-methylhydantoin
Dodatkowe informacje:
- SMILES: O=C1NC(=O)C(O)N1C
- Formula: C4H6N2O3
Specyfikacja/Zawartość:
- Purity: 0.995
- CAS#: 84210-26-4
- Molecular Weight: 130.1
- Bioactivity: NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
Inne:
For research use only.
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