CFTR Antibody / Cystic Fibrosis Transmembrane Regulator
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CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Dodatkowe informacje:
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Specyfikacja/Zawartość:
Human
Wysyłka i przechowywanie:
Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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