LAG3 Detection Set

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

Dodatkowe informacje:

Optimal dilutions for each application to be determined by the researcher.

Specyfikacja/Zawartość:

• Host Species: llama
• Species Reactivity: Human
• Homology: N/A
• Immunogen: LAG3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
• Tested Applications: E, IHC-P, IF, Flow
• Applications: N/A
• Specificity: N/A
• Purification: LAG3 Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.
• Clonality: Monoclonal
• Isotype: sdab
• Conjugate: Unconjugated
• Physical State: Liquid
• Buffer: LAG3 Antibodies are supplied in PBS.
• Concentration: Antibody 1 mg/mL
• Set Contents: 20 µg:
• LAG-3 Antibody [2A11], Cat. No. SD8837
• LAG-3 Antibody [1A6], Cat. No. SD8839
• LAG-3 Antibody [2B11], Cat. No. SD8841
• LAG-3 Antibody [1C6], Cat. No. SD8842
• LAG-3 Antibody [1A8], Cat. No. SD8843. 100 µg:
• cMyc-tag Antibody [5G5H7], Cat. No. PM-7669
• Products: SD8837, SD8839, SD8841, SD8842, SD8843, PM-7669

Wysyłka i przechowywanie:

• LAG3 antibodies should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Shipping Condition: Dry Ice

Inne:

For Research Use Only