TIGIT Antibody [10B1] (biotin)
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TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
Dodatkowe informacje:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Specyfikacja/Zawartość:
- Research area: Immunology
- Host species: Mouse
- Species reactivity: Human
- Homology: N/A
- Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT
- Tested Applications: E
- Applications: TIGIT antibody can be used for as detection antibody in Sandwich Elisa at 1 μ
- g/mL.
- Specificity: N/A
- Positive control 1: Cat. No. 1340 - Human Stomach Carcinoma Tissue Lysate
- Positive control 2: N/A
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: N/A
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: TIGIT Antibody is supplied as protein A purified IgG1.
- Clonality: Monoclonal
- Clone: 10B1
- Isotype: IgG1
- Conjugate: biotin
- Physical state: Liquid
- Buffer: TIGIT Antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: TIGIT
- Accession #: NP_776160
- Protein GI #: 256600228
- NCBI gene ID#: 201633
- NCBI official full name: T-cell immunoreceptor with Ig and ITIM domains
- NCBI organism: Homo sapiens
- SWISSPROT #: Q495A1
Wysyłka i przechowywanie:
- TIGIT antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Inne:
Optimal dilutions for each application to be determined by the researcher.
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