TIGIT Antibody [10B1] (biotin)

TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

Dodatkowe informacje:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Specyfikacja/Zawartość:

• Research area: Immunology
• Host species: Mouse
• Species reactivity: Human
• Homology: N/A
• Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT
• Tested Applications: E
• Applications: TIGIT antibody can be used for as detection antibody in Sandwich Elisa at 1 μ
• g/mL.
• Specificity: N/A
• Positive control 1: Cat. No. 1340 - Human Stomach Carcinoma Tissue Lysate
• Positive control 2: N/A
• Positive control 3: N/A
• Positive control 4: N/A
• Positive control 5: N/A
• Positive control 6: N/A
• Predicted molecular weight: N/A
• MW explanation: N/A
• Validation: N/A
• Isoforms: N/A
• Purification: TIGIT Antibody is supplied as protein A purified IgG1.
• Clonality: Monoclonal
• Clone: 10B1
• Isotype: IgG1
• Conjugate: biotin
• Physical state: Liquid
• Buffer: TIGIT Antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.
• Concentration: 1 mg/mL
• NCBI official symbol: TIGIT
• Accession #: NP_776160
• Protein GI #: 256600228
• NCBI gene ID#: 201633
• NCBI official full name: T-cell immunoreceptor with Ig and ITIM domains
• NCBI organism: Homo sapiens
• SWISSPROT #: Q495A1

Wysyłka i przechowywanie:

• TIGIT antibody can be stored at 4˚
• C for three months and -20˚
• C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Inne:

Optimal dilutions for each application to be determined by the researcher.