VGF Antibody
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VGF Antibody: VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
Dodatkowe informacje:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Specyfikacja/Zawartość:
- Research area: Neuroscience
- Host species: Rabbit
- Species reactivity: Human, Mouse, Rat
- Homology: Predicted species reactivity based on immunogen sequence: Bovine: (100%)
- Immunogen: VGF antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human VGF.
- The immunogen is located within the last 50 amino acids of VGF.
- Tested Applications: E, WB, IHC-P, IF
- Applications: VGF antibody can be used for detection of VGF by Western blot at 1 - 2 μ
- g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ
- g/mL. For immunofluorescence start at 20 μ
- g/mL.
- Antibody validated: Western Blot in human samples
- Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
- Specificity: N/A
- Positive control 1: Cat. No. 1303 - Human Brain Tissue Lysate
- Positive control 2: Cat. No. 10-301 - Human Brain Tissue Slide
- Positive control 3: N/A
- Positive control 4: N/A
- Positive control 5: N/A
- Positive control 6: N/A
- Predicted molecular weight: Predicted: 68 kDa
- Observed: 70 kDa
- MW explanation: N/A
- Validation: N/A
- Isoforms: N/A
- Purification: VGF Antibody is affinity chromatography purified via peptide column.
- Clonality: Polyclonal
- Clone: N/A
- Isotype: IgG
- Conjugate: Unconjugated
- Physical state: Liquid
- Buffer: VGF Antibody is supplied in PBS containing 0.02% sodium azide.
- Concentration: 1 mg/mL
- NCBI official symbol: VGF
- Accession #: NP_003369
- Protein GI #: 17136078
- NCBI gene ID#: 7425
- NCBI official full name: VGF nerve growth factor inducible
- NCBI organism: Homo sapiens
- SWISSPROT #: O15240
Wysyłka i przechowywanie:
- VGF antibody can be stored at 4˚
- C for three months and -20˚
- C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Inne:
Optimal dilutions for each application to be determined by the researcher.
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