TRAIL, Soluble Recombinant Protein
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TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to fi ve distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2;TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducingthe formation of the so-called multiprotein death-inducing signaling complex (DISC).
Specyfikacja/Zawartość:
- Tested Applications: N/A
- Applications: This recombinant proteins is for research use only.
- Predicted Molecular Weight: N/A
- Physical state: Lyophilized
- Buffer: Contains PBS. Reconstitute with 100 µl sterile water.
- Concentration: 0.1mg/ml after reconstitution.
- NCBI official symbol: TNFSF10
- Accession #: P50591
- Protein GI: 4507593
- NCBI gene ID#: 8743
- NCBI official full name: tumor necrosis factor (ligand) superfamily, member 10
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P08758
- Background Reference 1: N/A
- Background Reference 2: N/A
- Background Reference 3: N/A
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: E. coli
- Species: Human, Mouse
- By Source: E. Coli
- By Species: Human, Mouse
- Fusion tag: DDDDK Tag
- Sequence: The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a DDDDK-tag.
- Biology activity: Induces apoptosis of human Jurkat T cells in a concentration range of 5-50ng/ml in the presence of 1ug/ml TNF Ligands Enhancer (Prod. No. AG-35B-0001). In the absence of TNF Ligands Enhancer, TRAIL, Soluble (human) (recombinant) is poorly active.
- Purity: >95% (SDS-PAGE).
- Endotoxin level is less than 0.01EU/ µg purified protein (LAL test
- Lonza).
Wysyłka i przechowywanie:
Stable for at least 6 months after receipt when stored at -20°C.
Inne:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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