Rhesus macaque CTGF / CCN2 Recombinant Protein

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

Specyfikacja/Zawartość:

• Tested Applications: E, WB
• Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Predicted Molecular Weight: 37.3 kDa
• Physical state: Lyophilized
• Buffer: 5 mM HAC,100 mM NaCl, pH 5.5
• Concentration: N/A
• NCBI official symbol: N/A
• Accession #: N/A
• Protein GI: N/A
• NCBI gene ID#: N/A
• NCBI official full name: N/A
• NCBI organism: N/A
• Peptide sequence: N/A
• SWISSPROT #: N/A
• Background Reference 1: Faith Hall-Glenn., et al. 2011, Cell Mol Life Sci., 68(19), 3209–3217.
• Background Reference 2: Nakanishi T., et al. 2000, Endocrinology., 141(1), 264-73.
• Background Reference 3: Ball DK., et al. 2000, J Endocrinol., 176(2), R1-7.
• Background Reference 4: N/A
• Background Reference 5: N/A
• Source: HEK293 cells
• Species: Rhesus monkey
• By Source: Human Cells
• By Species: Other
• Fusion tag: His Tag
• Sequence: Gln 27 - Ala 349
• Biology activity: N/A
• Purity: >90% as determined by SDS-PAGE.

Wysyłka i przechowywanie:

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Inne:

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.