CD45 / PTPRC Recombinant Protein
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CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
Specyfikacja/Zawartość:
- Tested Applications: WB
- Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.8 kDa. The protein migrates as 120-170 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Predicted Molecular Weight: 62.8 kDa
- Physical state: Lyophilized
- Buffer: PBS, pH7.4
- Concentration: N/A
- NCBI official symbol: PTPRC
- Accession #: NP_002829.3
- Protein GI: N/A
- NCBI gene ID#: 5788
- NCBI official full name: proteintyrosinephosphatasereceptortypeC
- NCBI organism: Homo sapiens
- Peptide sequence: N/A
- SWISSPROT #: P08575
- Background Reference 1: Shen F.W. et al. Immunogenetics 24 (1986) 146–149.
- Background Reference 2: Charbonneau H. et al. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7182–7186.
- Background Reference 3: Rheinländer A. et al. Immunol Lett. 2018 Apr
- 196:22-32.
- Background Reference 4: N/A
- Background Reference 5: N/A
- Source: HEK293 cells
- Species: Human
- By Source: Human Cells
- By Species: Human
- Fusion tag: His Tag
- Sequence: Gln 26 - Lys 577
- Biology activity: N/A
- Purity: >90% as determined by SDS-PAGE.
Wysyłka i przechowywanie:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Inne:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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