Anti-Caspase-9 antibody

Caspase-9 is a protein encoded by the CASP9 gene which is approximately 46,2 kDa. Caspase-9 is localised to the cytosol, mitochondrion and nucleus. It is involved in the TNFR1 pathway, RET signalling and apoptosis modulation and signalling. Caspase-9 exist as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase-9 is ubiquitously expressed with highest expression in the heart. Mutations in the CASP9 gene may result in cerebral hypoxia and cervical cancer. STJ92029 was affinity purified. This poly clonal antibody binds endogenous caspase-9.

Specyfikacja/Zawartość:

• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Applications: WB,IHC,IF,ELISA
• Reactivity: Human
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Clone: NA
• Concentration: 1 mg/ml
• Gene: CASP9
• Immunogen: Synthesized peptide derived from human Caspase-9 around the non-phosphorylation site of S196.