Recombinant Human PDGF-AB Protein
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PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
Specyfikacja/Zawartość:
- category: Recombinant Proteins
- gene name: Pdgfa
- contents: Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.
- uniprot_id: P20033
- form: Solid
- white powder or thin/invisible film
- purification: NA
- applications: Cell Culture
- subcellular_localization: Secreted. Released by platelets upon wounding.
- source: E. Coli
Wysyłka i przechowywanie:
Store in -20°c for long term storage. After reconstitution, store in 4°c for short term usage within a few days. Avoid freeze-thaw cycles.
Inne:
this product is available in other size, Various Sizes, please contact us for more information.
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