ELISA kit for Human Apoptosis protease activating factor-1 (APAF1)
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Quantitative sandwich ELISA for measuring Human Apoptosis protease activating factor-1 (APAF1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Dodatkowe informacje:
Apoptotic peptidase activating factor 1 is a proteincontains several copies of the WD40 repeat domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.Alternative splicing results in several transcript variants encoding different isoforms.
Specyfikacja/Zawartość:
- Reactivity: Human
- Sample types: serum, whole blood, plasma and other biological fluids
- Detection range: Please inquire
- Sensitivity: Please inquire Quantitative Sandwich ELISA
- Method of detection: Colorimetric
Wysyłka i przechowywanie:
All of the components are shipped on ice packs/blue ice. Upon receiving the kit keep it at +4 degrees Celsius for up to 1 year (refer to the label on the box for the exact expiration date).
Inne:
This kit is intended for research use only. It should not be used for human or animal clinical diagnostics or treatment.
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